Dr. Lora Hurley, ND, CTN, CHP, ICHT, CPT says "There is a TH1 and TH2 side of the immune system to be considered.  Cytokines are intended to work like messengers to "drive" these sides.  T Regulatory cells help to guide this movement and require "ingredients" to make good decisions for you.  TH17 modulation is desired, as it can cause tissue breakdown, drive inflammation, mood disorders, addictions, auto immune dysregulation and perhaps cancers.  It can be driven by I NOS.  In her opinion, she says that; "If there is a problem with a gene, (either one turns on that does something you do not want it to do, or a gene turns off that does something you want it to do, or there can be a epigenetic caused new mutation), electro/magnetics, auto immune dysregulation, diet and nutrition, toxins, pathogens, etc.; a person can become dominate on one of the TH1 or TH2 sides of the immune system.  For this reason, until variables like the ones listed above are supported CORRECTLY, one should NEVER try to "boost" the immune system.  Dr. Hurley has cared for auto-immune cases for over 2 decades now and her opinion is:  "One should support immune modulation for the above reasons.  This can give the immune system the ability to make better decisions for your health.  Be aware that most of the immune system lies in the gut, so anything that happens in the gut affects the brain and anything that affects the brain, affects the body globally.  If one "boosts" the immune system without proper guidance to do so, they may get much worse instead of better".  Call Hurley Wellness Center today to schedule your appointment with Dr. Hurley and for all of your wellness needs.  To see how complex the immune system can be, the information provided in the chart below is easily found in research areas like  It is provided for educational purposes only to help you gather a better understanding of health. 


Cytokines are powerful communication molecules capable of regulating a wide spectrum of biological functions, including

a crucial role in the immuno-pathogenesis of disease. Two general constellations of cytokines are associated with

functional immune responses. These are classified as either TH1 or TH2 and can be distinctly observed during disease.nIne Disease*



IL-2 Interleukin-2 Inflammation

IL-12 Interleukin-12 Autoimmune diseases (RA, MS, IDDM), tumor, Graft vs. Host Disease,

Infections, HIV, Glomerulonephritis

IFN- Interferon- Inflammatory diseases (infection, Dermatitis), autoimmune diseases (RA, MS,

IDDM, SLE), tumors, Hepatitis B and C

TNF- Tumor necrosis factor-

Inflammatory diseases, autoimmune diseases (RA, IDDM, MS, CD), Psoriasis,

chronic Hepatitis B and C, SLE, tumors, chronic lymphatic Leukemia,




IL-4 Interleukin-4 Asthma, Allergy, Malaria, Hepatitis C

IL-5 Interleukin-5 Asthma, Allergy

IL-6 Interleukin-6 Inflammatory diseases (viral and bacterial infection), autoimmune disease (RA,

SLE, etc.), Schizophrenia

IL-10 Interleukin-10 Autoimmune disease, IgE-mediated Asthma, Hepatitis B and C, IBD, Septic

shock, mostly during recession of diseases

IL-13 Interleukin-13 Asthma, Allergy, COPD

GM-CSF Granulocyte-macrophage colonystimulating

Factor Inflammation (bacterial infection, Asthma), autoimmune diseases, toxic shock



IL-17 Interleukin-17 Inflammatory diseases (inflammatory airway diseases), autoimmune diseases

(RA, MS, Crohn’s Disease, etc)



IL-1 Interleukin-1 Inflammatory diseases (Periodontitis, Colitis, IBD), autoimmune diseases (RA,

IDDM, MG), Schizophrenia

IL-7 Interleukin-7 Osteolytic Cancer, Lymphopenia, high in untreated advanced HIV patients and

in those who fail to respond to HAART therapy

IL-8 Interleukin-8 Autoimmune diseases (RA, Crohn’s disease), Uveitis, Colitis, acute

inflammatory diseases

G-CSF Granulocyte colony stimulating factor Acute bacterial infection, cyclic neutropenia

MCP-1 Monocyte chemoattractant protein-1

Inflammatory diseases (Glomerulonephritis, Allergy), Atherosclerosis,

Neoplasm, human immunodeficiency infection, autoimmune diseases (RA,

MS), Alzheimer’s disease

MIP-1 Macrophage inflammatory protein-1 Acute infections such as bacterial Sepsis, Plasmodium, HIV, lung disease-

Sarcoidosis, autoimmune diseases (RA, MS), Colitis, Asthma

TGF- Transforming growth factors-

Inflammation, wound healing, bone formation, fibrotic conditions,

carcinogenesis, immunosuppressive disorders, neurodegenerative disease,

coronary artery disease, SLE, RA

*This chart is not to be used for diagnostic purposes. This is only for general information on the role cytokines might play in human disease.

Pro-inflammatory cytokines Anti-inflammatory cytokines Chemokines






Dr. Lora Hurley Lora Hurley, ND, CHP, CTN, ICHT, CPT, is a double board-certified naturopathic physician through the American Naturopathic Medical Certification Board and the American Naturopathic Certification Board. She is also a board certified Clinical Hyperbaric Practitioner through the International Board of Undersea Medicine. Currently, she is enrolled in ongoing cme courses with Dr. Paul Anderson, NMD, professor Bastyr University and with US Navy approved Hyperbaric and Undersea Medicine. She is also continuing education in wound healing with the American College of Hyperbaric Medicine and Hyperbarics International. Additionally, some of her postdoctoral studies have included endocrinology, immunology, genetics, and neurology. Dr. Hurley is also certified in clinical microscopy, live-blood cell analysis, lymphatic tissue detoxification, and is nationally certified as a phlebotomist.

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